Effect of intranasal administration of γ-aminobutyric acid on intraspecies aggression of male mice

Abstract

Intranasal administration of γ-aminobutyric acid (GABA) modifies the behavior of male mice in the intraspecies aggression model. Low doses of GABA (0.5 mg/kg) considerably decrease the number of attacks for several days. Systemic administration of GABA in high doses (100 mg/kg) induces short-term changes in the aggressiveness of male mice. It is hypothesized that intranasally administered GABA enters the central nervous system without crossing the blood-brain barrier.