Effect of a preparation of exogenous histone administered by different routes on intraspecific aggression in male mice

Abstract

A study is made of the effect of a preparation of exogenous histone from calf thymus administered intranasally and intraperitoneally on intraspecific aggression in male mice. The histone is shown to exert a short-term suppressive effect on aggression with both routes of administration which manifests itself in a reduced number of attacks. However, the effective doses with intranasal administration are considerably lower than in the case of intraperitoneal injections.