Effect of Intensive Phase Anti-tubercular Treatment on Hematological Parameters in Pulmonary Tuberculosis in Children

Abstract

Aim and objectives: To study the effect of intensive phase ATI on various hematological parameters in pulmonary TB in children. Material and methods: Study design: Prospective observational study. Children were chosen at random from children who were identified and diagnosed at the Dr. Ram Manohar Lohia Hospital in New Delhi's Atal Bihari Vajpayee Institute of Medical Sciences using a straightforward sampling technique. Every patient is diagnosed with pulmonary tuberculosis based on RNTCP standards. The research was conducted from November 2019 to March 2021 (one year four months). Results: Hemoglobin count (t-value -2.914), Red Blood Cells (t-value -4.338), Platelet Count (t-value -4.762), Lymphocytes (t-value -4.472), Monocyte (t-value 5.991),ESR count (t-value 5.118), Packed Cell Volume (t-value -4.228), Mean Corpuscular Volume (t-value -3.418), Platelet Large Cell Ratio (t-value -4.254), C-reactive count (t-value 3.131), Ferritin (t-value 4.747), X-ray (t-value 5.213) significant at <0.05 level respectively. Conclusion: The various parameters used in the study as the inflammatory process have an extremely important part in the TB pathogenesis. These parameters can be used as markers can be used for prognosis, response to treatment, and follow-up purposes. It can increase the predicting accuracy of treatment outcomes as ones can monitor the TB cases objectively in addition to subjective parameters (improvement in clinical symptoms and examination findings, weight gain, Increase in appetite). Anti-tuberculosis Drug Treatment (ATT) is highly successful in enhancing hematological parameters, which suggests that responders' immune responses have improved in an indirect manner.