Abstract
Background: This study was done to investigate the effects of injectable trace minerals on the humeral immune response of dairy cows receiving multivalent viral vaccine. Materials and methods: Forty cows divided into 2 groups; average BW = 350 - 420 kg. All were seronegative for FMD virus, lumpy skin, BFV, BVD and IBRV. First group (Gp1) n= 20 Holstein cows vaccinated with FMD virus, lumpy skin, BFV, BVD and IBRV, and the 2 nd group (Gp2) vaccinated and treated with injectable trace mineral supplement 7 mL subcutaneous (MultiMin 90, USA) containing Cu, Zn, Mn (all as disodium EDTAsalts), and Se. Humoral immunity was detected by neutralizing antibody titers measured on day one, 7th week and 14th weeks experiment relative to vaccines administration. All cows were seronegative for each of the 5 viruses on day zero, serum mineral concentrations were evaluated on day one, 7 w and 14 w. Results: The higher average of milk production in 7 th and 14th week in the Gp2 compared to Gp1, there are clear increases in the concentration of minerals (Cu, Zn, Se, Mo, Co, Mn, Fe) in Gp2 compared to Gp1, which indicates better absorption of these minerals when they are injection. The mean antibodies titers were gradually increased from 7th weeks post-vaccines till reached higher level at 14th weeks post- vaccines for all viral vaccines as measured by SNT and ELISA test. The antibodies peak titer was observed higher at 14th w post-vaccination in Gp2 significantly greater than Gp1. Conclusion: Viral vaccination concurrent with ITM, induced a rapid protection against viral infection. In addition, administration of ITM at the time of vaccination was associated with increased humoral immune response, enhanced health status
Published Version
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