Effect of inhalation of fluticasone propionate aerosol on mild to moderate asthma in children and its effect on airway inflammatory response

Abstract

Objective To investigate the effect of inhalation of fluticasone propionate aerosol on mild to moderate asthma in children and its effect on airway inflammatory response. Methods From March 2015 to March 2017, 90 children with mild to moderate asthma were selected as the research subjects. According to the treatment method, they were divided into control group (n=45, budesonide) and observation group (n=45, on the basis of control group, the atomization inhalation treatment of fluticasone propionate aerosol was given). Results After treatment, the total effective rate of observation group was 96.77% (43/45), which was better than that of control group [4.44% (38/45), P<0.05]. After treatment, lung function index levels of the two groups of children were improved (P<0.05), with greater improvement in observation group (P<0.05); after treatment, the airway-related inflammatory factors and interleukin-37 (IL-37) in both groups were significantly improved (P<0.05), and the observation group was significantly superior to the control group (P<0.05). The IL-37 level of observation group was (26.96±3.98) pg/ml, which was (30.96±3.24) pg/ml in control group, the difference between the two groups was significant (P<0.05). Conclusions Nebulization and inhalation of fluticasone propionate aerosol in the treatment of children with mild and moderate asthma, can effectively improve the lung function and inflammatory factors and improve the symptoms of children, and has a high clinical value. Key words: Fluticasone propionate aerosol; Atomization inhalation treatment; Mild-to-moderate asthma; Airway inflammatory reaction