Abstract
The concentration of nicotinamide coenzymes (NAD, NADH, NADP, and NADPH) was determined in tissues of the brain, heart, and liver of newborn rats exposed for 2.5 h to a hypoxic atmosphere containing 4% oxygen. A marked decrease in the NAD content, an increase in NADH, and a decrease in the NAD/NADH ratio by more than half were observed in the experimental animals and the changes were particularly marked in the brain and heart. Under the same conditions there was a decrease in the NADPH content, chiefly in the liver, and in the total reserves of NAD-phosphates in the tissues of the newborn rats studied. It is suggested that hypoxia has a substantial effect on the absolute and relative concentration of nicotinamide coenzymes in the tissues of newborn rats, resulting in changes in the level and direction of oxidoreductive processes under hypoxic conditions.
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