Abstract
Hexokinase (HK) activity in the total homogenate and cytoplasmic and mitochondrial fractions of the brain, heart, and liver of newborn rats was studied in relation to the severity of exposure to hypoxia. With a mild form of hypoxic hypoxia an increase in the activity of the mitochondrial-bound form of the enzyme was observed in the brain and liver tissue accompanied by a decrease in cytoplasmic HK activity and, in the brain, by a marked increase in the rate of glucose phosphorylation. Deep hypoxia led to a decrease in HK activity in the total homogenate and in both subcellular fractions in all tissues investigated. The results point to a disturbance of certain mechanisms in the tissues of newborn rats after exposure to a severe degree of hypoxia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
