Abstract
SummaryThree groups of 50 rats each were exposed for periods of up to 24 days to either hypoxia (70 Torr PIO2), hypercapnia (140 Torr PIO2, 60 Torr PICO2), or a combination of this level of hypoxia and hypercapnia.The combined condition resulted in a much smaller rise in circulating red cell volume per body weight than in rats exposed to hypoxia alone. The increase that did occur could be mainly attributed to a release of stored red cells into the circulation. During hypercapnia, plasma volume increased with only small changes in numbers of circulating red cells. This resulted in a depression of hematocrit.It is still not clear whether concomitant hypercapnia increased oxygen levels in the hypoxic-hypercapnic rats sufficiently to remove the erythropoietic stimulus, or if CO2 actually inhibited erythropoiesis.
Published Version
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