Abstract
IN THE preceding paper (Talbert, Meyer, and McShan, 1951) a study was made of the effect of hypophysectomy at the beginning of proestrus on the ability of mature follicles to ovulate in response to an intravenous injection of chorionic or pituitary gonadotrophin. That investigation was extended to include a study of histological changes which occur in maturing follicles following removal of the pituitary gland. It was determined in this study that mature follicles lose their ability to ovulate within 8 to 12 hours following hypophysectomy at the beginning of proestrus but no histological changes were detected until 19 hours following the operation. At this time a definite increase in pyknotic granulosa cell nuclei was noted but degenerative changes in the ova in these follicles were not apparent until many hours later. Although the ova appeared by histological examination to be normal 6 to 8 hours following hypophysectomy
Published Version
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