Abstract
Natural killer (NK) cells, a subset of lymphocytes, have the ability preferentially to kill virus-infected cells and certain tumor cells in vitro (Herberman et al. 1979). NK cells have been proposed to represent a first level defense mechanism against tumor development and tumor spread in vivo (Herberman 1981; Pollack and Hallenbeck 1982). A correlation between defective NK activity and an increased incidence of malignant disease both in man and in mice supports this concept (Haliotis et al. 1980; Talmadge et al. 1980).
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