Abstract
Objective To explore the effect of hyperbaric oxygen therapy (HBOT) on learning and memory of rats with cerebral ischemia. Methods 38 male Sprague-Dawley rats were randomly divided into 4 groups : the control group ( n = 10 ), the sham operation group ( n = 10 ), the cerebral-iscbemia group ( n = 9 ) ,and the HBO group (n = 9). According to Pulsinelli's 4-vessel occlusion method, the cerebral-ischemia model was developed. The HBO group received HBO therapy the same day after surgical operation once a day for 7 days in succession. Then, all the rats except those of the control were given a test of Morris water-maze or 6 successive days. An observation on the time of escape latency and the number of times they ran across the platform was made on the 6th day. Results ( 1 ) Comparison of escape latency for the first 5 days. Escape latency for the HBO group was shorter than that of the cerebral ischemia group from the 3rd to 5th day (P＜0.01or P ＜ 0.05 ) ; No statistical difference could be noted in latency time, when a comparison was made between the HBO group and the sham operation group from the 1st to 5th day; Escape latency for the cerebral ischemia group on the 3rd and 5th day was greater for the sham operation group ( P ＜0. 01 or P ＜0.05 ) ; Escape latency for the control group was shorter than the sham operation group from the 2nd to 5th day ( P ＜ 0.01 or P ＜ 0.05 ).( 2 ) Comparison of the number of times that the rats ran across the platform on the 6th day. The number of times for the HBO group was greater than the cerebral ischemia group ( P ＜ 0. 05 ) ; No statistical difference could be seen, when a comparison was made between the HBO group and the sham operation group; The number of times for the cerebral ischemia group was smaller than that of the sham operation group (P ＜0. 01 ) ; The number of times for the control group was greater than that of the sham operation group ( P ＜ 0. 01 ). Conclusions HBO can improve learning and memory of rats following cerebral ischemia in rats. Key words: Hyperbaric oxygen; Cerebral ischemia; Learning; Memory
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call