Abstract
To elucidate the physiological significance of ketone bodies on insulin and glucagon secretion, the direct effects of β-hydroxybutyrate (BOHB) and acetoacetate (AcAc) infusion on insulin and glucagon release from perfused rat pancreas were investigated. The BOHB or AcAc was administered at concentrations of 10, 1, or 0.1 m m for 30 min at 4.0 ml/min. High-concentration infusions of BOHB and AcAc (10 m m) produced significant increases in insulin release in the presence of 4.4 m m glucose, but low-concentration infusions of BOHB and AcAc (1 and 0.1 mM) caused no significant changes in insulin secretion from perfused rat pancreas. BOHB (10, 1, and 0.1 m m) and AcAc (10 and 1 m m) infusion significantly inhibited glucagon secretion from perfused rat pancreas. These results suggest that physiological concentrations of ketone bodies have no direct effect on insulin release but have a direct inhibitory effect on glucagon secretion from perfused rat pancreas.
Published Version
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