Abstract
The effect of hydrocortisone was studied on the following stages of immunogenesis: migration of hematopoietic stem cells from the bone marrow; migration of B lymphocyte precursors of antibody-forming cells; cooperative interaction of T and B lymphocytes in the primary immune response to antigenic stimulation by sheep's red cells. Experiments were carried out on F1(CBA x C57BL) mice. Hydrocortisone, in doses not inhibiting proliferation of hematopoietic cells, had a marked immunodepressive effect which was the resultant of inhibition between different stages of immunogenesis: migration of stem cells and B lymphocytes and cooperation between T and B lymphocytes.
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