Abstract
Migration and differentiation of hematopoietic stem cells were studied in autoimmune (NZB×NZW)F1 mice of different ages. Migration of stem cells was shown to be reduced in old (NZB×NZW)F1 mice. Irrespective of age, inhibition of differentiation of stem cells along the granuloid path of development was observed in (NZB×NZW)F1 mice. It is suggested that in (NZB×NZW)F1 mice there is either a defect of development of the T-lymphocyte subpopulation influencing differentiation of stem cells along the granuloid pathway or a genetic defect at the level of precursors of the granulocyte series (CFUC).
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