Abstract
Previous work has indicated that hGH has quantitatively significant effects on drug elimination in human children. For many substrates, such as amobarbital, which are metabolized by the hepatic MFO system, elimination is slowed (G.P. Redmond, et al. Clin Pharmacol Ther 24:213, 1978). We wished to determine whether hepatic conjugation reactions are also altered by hGH treatment. 5 children were given APAP orally in a dose of 10 to 15 mg/kg before and again 6 weeks after hGH replacement therapy. HGH was generously supplied by the National Hormone and Pituitary Program (NHPP); all children met NHPP criteria for hGH deficiency. Preliminary results on 3 children are as follows:These results indicate that elimination of APAP by hGH deficient children is similar to the 1.74 hr t½ observed in normal febrile children (J.T. Wilson, et al. Ther Drug Monitoring 4:147, 1982). HGH replacement did not affect t½, Td or Cl. Studies of urinary metabolites are in progress to determine whether the ratio of sulfate to glucuronide is altered.
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