Abstract
Confluent, non-dividing monolayers of WI-38 human diploid fibroblasts can be stimulated to synthesize DNA and divide by a change of medium and serum. Within one hour of stimulation there is an increase in the template activity for RNA synthesis of chromatin. This change in chromatin template activity is seen using either a heterologous E. coli or a homologous HeLa cell RNA polymerase. This strengthens the conclusion that genome activation is one of the earliest changes in the stimulated cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
