Abstract
Objective: To investigate the effect of high fructose diet during pregnancy on insulin resistance in the offspring. Methods: normal diet Wistar adult male rats and female rats were mated and pregnant rats were randomly divided into five groups: normal control group, normal dose group, high dose of fructose fructose group, high dose group and high dose of sucrose fructose group were given daily during pregnancy, 2mL of distilled water, 2g/kg 18g/kg, 6g/kg, 18g/kg and the fructose solution of sucrose solution by gavage, continuous intervention until delivery, delivery of rats fed with basic diet, and the rats weighing body weight, fasting blood glucose. The OGTT test was conducted at the end of the eighth week. After the next day of fasting 12h, the rats were killed, anesthesia, blood extraction, liver HE staining, serum insulin level, and insulin resistance index were measured. Results: during continuous intervention, birth weight childbirth offspring rats; OGTT test: at 30min, high dose group, high dose of fructose fructose group and high dose glucose sucrose group were significantly higher than normal control group and normal group (P<0.05), fructose dose at 120min, high dose group, high dose of fructose fructose group and high dose glucose sucrose group were significantly higher than normal control group (P<0.05). The serum insulin and insulin resistance index of high dose fructose group, super high fructose group and super high sucrose group were significantly higher than those of normal control group and normal dose fructose group (P<0.05). The liver slices of high fructose group and super high fructose group showed fat accumulation. Conclusion: high fructose diet during pregnancy could increase the risk of progeny metabolic syndrome.
Highlights
With the rapid development of society, people's living standard is increasing
Great changes have taken place in our country residents' dietary pattern: People's dietary patterns from a plant-based diet for Japanese dietary patterns gradually changed to animal food based dietary patterns in developed countries, it is the prevalence of chronic diseases increased: especially obesity and diabetes non communicable chronic metabolic the prevalence of the disease compared with 2002 increased
As fructose compared with sucrose, the advantage is obvious, so fructose is widely used in food processing and gradually replace sucrose
Summary
With the rapid development of society, people's living standard is increasing. great changes have taken place in our country residents' dietary pattern: People's dietary patterns from a plant-based diet for Japanese dietary patterns gradually changed to animal food based dietary patterns in developed countries, it is the prevalence of chronic diseases increased: especially obesity and diabetes non communicable chronic metabolic the prevalence of the disease compared with 2002 increased. The results of glucose tolerance test in each group Different doses of fructose intake group delivered rats OGTT test in eighth weeks. At 30min, the blood glucose values of HF group, SHF group and SHS group were all higher than those of BC group and NF group, with a statistically significant difference (P < 0.05). The blood glucose values of SHF group and SHS group were significantly different from those of NF group (P < 0.05). Effects of fructose intake at different doses in pregnancy on the level of insulin and the degree of IR in the offspring The value of fasting blood glucose in group SHF and group SHS was significantly higher than that in group BC, and the difference was statistically significant (P < 0.05). The fat accumulation in the high dose fructose group was more serious
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