Abstract
Intestinal flora plays an important role in inflammatory response to systemic or local organs of its host. High calorie diet has been shown to aggravate the condition of pneumonia and delay recovery, especially in children. However, the underlying mechanisms remain unclear. This study placed SPF rats in a conventional environment, high calorie diet or LPS atomization was performed respectively or combined. Analysis of high-throughput sequencing of intestinal content combined with animal weight, organ index, serum inflammatory factors indicators and bioinformatics found that after pulmonary infection combined with a high-calorie diet, rats showed significant changes such as weight loss and increased lung weight index, and their lung and intestinal tissues showed more obvious inflammatory changes. And its gut flora structure suggests, the abundance of Leuconostocaceae in significantly reduced; abundance of Staphylococcus, Planococcaceae, Staphylococcus, Staphylococcaceae, Bacillales, Gemellales and Aerococcus significant increased. The study showed that high calorie diet and LPS atomization synergistically promoted pneumonia process in rat pups, which is related to changes in structure of intestinal flora. It is worth noting that pneumonia rats fed by convention diet also causing intestinal flora imbalance.
Highlights
Long-term high calorie diets have a negative regulatory effect on health
Compared with normal control group (NC) group, the body weight of MC3 group decreased after high calorie diet, and the difference was statistically significant
Compared with NC group, there was no significant difference in rectal temperature between groups after high calorie diet
Summary
Long-term high calorie diets have a negative regulatory effect on health. Studies have shown that[1] high calorie diet may aggravate the condition of pneumonia and delay recovery in respiratory infectious diseases. Changes in the rhythm of modern life caused changes in structure of intestinal flora[2], such as dietary imbalances[3,4]. It is suggested that changes in dietary composition may cause changes in internal ecosystem of intestine[5]. The hypothesis theory of “pulmonary-gut axis”[6] indicates that local inflammatory reactive substances of respiratory system and products of intestinal flora metabolism exchanged and stimulated through lymphatic system and blood circulation system. It is still unclear whether intake of high calorie diet aggravates inflammatory response of respiratory tract influenced by intestinal flora. This study explored potential influence of high calorie diet on aggravating pneumonia rats in intestinal flora
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