Effect of Hedan tablet on expression of serum adipocytokines and inflammatory factors in rats with metabolic syndrome

Abstract

Objective To investigate the effects of Hedan tablet on serum adipocytokines and inflammatory factors in rats with metabolic syndrome. Methods The 24-rat model of metabolic syndrome were randomly divided into three groups(n=8, each): normal group were given normal diet, model group were given high-lipid and high-salt diet and intervention group were given high-lipid and high-salt diet plus Hedan tablet 6.0 g·kg-1·d-1 by intragastric administration for 3 weeks.Body weight, blood pressure, blood levels of glucose, lipid, leptin, visfatin, adiponectin and CRP were measured in all rats at the beginning and the end of the study. Results Compared with normal group, model group(model versus normal)showed significantly increased serum levels(P<0.05)of weight, total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), glucose, leptin(5.5±0.1 vs.5.2±0.0 mmol/L), visfatin(17.5±0.5 vs.16.6±0.0 mmol/L and CRP(1 676.6±74.8 vs.1 642.3±52.2 mmol/L), and showed significantly decreased(P<0.05)serum level of adiponectin(74.6±2.4 vs.81.3±2.1 mmol/L). Compared with 20 weeks of age group, the 23 weeks of age group(23 weeks versus 20 weeks)showed significantly decreased levels of weight, TC, TG, LDL-C, serum leptin(5.4±0.1 mmol/L vs.5.9±0.2 mmol/L), visfatin(16.7±0.4 mmol/L vs.17.7±0.6 mmol/L)and CRP(1 498.8±51.0 mmol/L vs.1 682.1±76.6 mmol/L(all P<0.05), and showed significantly increased serum adiponectin level(81.2±3.0 mmol/L vs.73.9±3.1 mmol/L)(P<0.05). But there was no significant change in model group between 20 weeks and 23 weeks of age. Conclusions Hedan tablet reduces the body weight and ameliorates blood lipid level in rats with metabolic syndrome.These effects may be related to regulation of Hedan tablet on adipocytokines and inflammatory factors. Key words: Hedan tablet; Metabolic syndrome; Adipokines; Inflammatim mediators