Abstract
SummaryPreliminary studies showed that weanling Long-Evans rats are less susceptible to goldthioglucose than are adults; the LD50 for 50 g animals was 0.25 mg/g. Some adult Sprague-Dawley rats were found to withstand doses of GTG that were lethal to adult Long-Evans rats, and to demonstrate a developing obesity. More severe VMH lesions were seen in female than in male rats following GTG injection. Glial damage without neuronal destruction appeared in several GTG-injected rats. Treatment with phlorhizin and BAL reduced renal damage produced by GTG injection. GTG injection, in adult rats, produced a triphasic blood-glucose pattern.
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