Abstract
THE PRESENT experiment constitutes a preliminary report on the effect ofl(+)-glutamic acid on the mental function of persons with mongolism. The problem presents itself naturally, since the disease, as one of the most serious and least understood forms of mental deficiency, epitomizes the basic problem of the mechanism of intelligence. The distinct concomitant anatomic features of the mongolian idiot likewise underscore the psychosomatic relationship and essential unity of mind and body for medicine when it is inclined to relegate the problem of the mind to the more philosophic disciplines alone. This intimate body-mind relationship was not overlooked by earlier investigators. In a classification of idiots, J. Langdon Downs, in 1866, gave the first description of mongolism as a morbid entity. In the same year, Seguin,1although considering mongolism as a variant of cretinism, also gave a precise description of the condition. More recently, Benda2revealed his
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