Effect of glitazones on cancer mortality in type 2 diabetes

Abstract

aim: Stroke has a major impact on the individual and our health care system. Diabetes is an established risk factor for ischemic stroke and also appears to increase the risk of hemorrhagic stroke. This time-series analysis compared population-based rates of acute ischemic strokes (AIS), transient ischemic attacks (TIA), and hemorrhagic strokes between Alberta residents with and without diabetes. Methods: Administrative databases from Alberta Health and Wellness were used to identify hospitalizations with a most responsible diagnosis of stroke for all Alberta residents >=20 years old between 2003 and 2007. Alberta is one of ten provincial jurisdictions in Canada with a population of approximately 3.4 million people living in diverse regions. The Canadian National Diabetes Surveillance System algorithm was used to identify people with diabetes. The pathological type of stroke was grouped into three categories: AIS (ICD-9 codes 362.3, 433, 434 & 436 [excluding 433.X0 and 434.X0]; ICD-10 codes H34.1, I63 & I64), TIA (ICD-9 code 435; ICD-10 codes G45, G45.0, G45.1-G45.3, G45.8 & G45.9), and hemorrhagic stroke (ICD-9 codes 430 or 431; ICD-10 codes I60 or I61). Annual ageand sex-standardized rates for each stroke type were compared between Albertans with and without diabetes across the observation period (2003-2007). results: The annual ageand sex-standardized rates (per 10,000 people) by type and diabetes status are presented in the following table.