Effect of Gexia Zhuyu Decoction for patients with qi stagnation and blood stasis liver cancer and its influence on liver function

Abstract

Objective To investigate the effect of Gexia Zhuyu Decoction for patients with qi stagnation and blood stasis liver cancer and its influence on liver function. Methods A total of 100 patients with qi stagnation and blood stasis liver cancer treated at our hospital from May, 2014 to May, 2019 were randomly divided into a control group and a study group, with 50 patients in each group. The control group was treated with given FOLFOX4 systemic chemotherapy, and the study group with Gexia Zhuyu Decoction. The total clinical effective rates and levels of ALT, TBIL, HA, LN, and PCⅢ were compared between these two groups. Results The total effective rate was higher in the study group than in the control group [92.0% (46/50) vs. 64.0% (32/50); P<0.05]. After the treatment, the levels of AFP, ALT, TBIL HA, LN, and PCⅢ were lower in the observation group than in the control group [(401.5±102.1) μg/L vs. (678.7±129.6) μg/L, (41.1±13.7) U/L vs. (83.2±21.9) U/L, (9.1±2.2) μmol/L vs. (19.4±5.3) μmol/L, (168.2±12.7) μg/L vs. (301.7±14.5) μg/L, (158.7±14.8) μg/L vs. (351.2±29.9) μg/L, and (11.3±3.7) μmol/L vs. (22.5±6.2) μmol/L; all P<0.05]. Conclusion Gexia Zhuyu Decoction for patients with qi stagnation and blood stasis liver cancer is effective, and can effectively improve their liver function and reduce their symptoms of liver fibrosis, so it is worth being clinically generalized. Key words: Gexia Zhuyu Decoction; Plus or minus treatment; Qi stagnation and blood stasis type; Liver cancer; Liver function indicators