Abstract
The effect of tablet thickness on the hydration kinetics of types I and II theophylline anhydrate tablets at 95% relative humidity and 35°C was studied with various kinetic equations. Samples of 1‐ and 2‐cm‐diameter tablets (1 g) were compressed at 1000 kg/cm2. Types I and II tablets expanded by 11–17% in volume during hydration to the monohydrate. The thickness expansion of all tablets exceeded the diameter expansion. After the hygroscopicity test, the final expansion ratio of type I tablets was more than that of type II tablets. The hydration kinetics analysis suggested that the hydration of theophylline anhydrate tablets proceeds as follows: Hydration of the 1‐cm‐diameter type I tablet followed the two‐dimensional phase boundary equation, and that of the 1‐cm‐diameter type II tablet followed the three‐dimensional phase boundary equation, but those of the 2‐cm‐diameter types I and II tablets followed the equation for two‐dimensional growth of nuclei. The hydration kinetics of tablets does not depend on the nature of bulk powder but on geometrical factors (tablet thickness and porosity).
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