Abstract
This study was designed to characterize the chemical composition, anti-oxidant activity, anti-inflammatory, and hepatoprotective effect of the polysaccharide a galactofucan sulfate (GFS) from brown seaweed Lobophora variegata. Chemical characterization was performed by several chemical methods, high-pressure liquid chromatography (HPLC), nuclear magnetic resonance (NMR) (1H, 13C, heteronuclear multiple quantum correlation (HMQC), and 1H-1H COSY), and infrared spectroscopies. The results showed an acidic polysaccharide with a high level of sulfated fucose and galactose. GFS displayed anti-oxidant effects acting directly on the free radicals. Pretreatment with fucans in mice induced by carbon tetrachloride (CCl4) administration resulted in a significantly inhibited increase in the blood enzymatic activities and bilirubin level. Administration of GFS (75 mg kg−1) reduced (p < 0.01) the activities of enzymes. This was shown by assessment of hepatic markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamil transferase (γ-GT), and bilirubin reduction in serum. Histological analysis of the liver confirmed the effects of fucans on hepatoprotection. This fucan affects time of sodium pentobarbital-induced sleep, also demonstrating its effect on hepatic recuperation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
