Effect of Fuyankangfupian in the treatment of patients with miscarriage caused by chronic endometritis and its influence on the inflammatory factor

Abstract

Objective To study the clinical effect of Fuyankangfupian in the treatment of patients with miscarriage caused by chronic endometritis and its influence on the inflammatory factor. Methods A total of 80 patients with miscarriage caused by chronic endometritis were enrolled in this study.The subjects were randomly divided into control group(n=40) and observation group(n=40). The control group was treated with conventional treatment, the experiment group was treated with Fuyankangfupian combined with conventional treatment.The clinical indicators, the visual analogue scale(VAS), serum levels of TNF-α, hs-CRP and IL-2 of the two groups before and after treatment were recorded and compared. Results After treatment, the abdominal pain time[(2.96±0.88)d], bleeding time[(4.51±1.12)d]and blood loss[(102.16±21.82)mL]of the observation group were significantly lower than those of the control group[(6.83±1.32)d, (7.14±1.50)d, (174.28±33.35)mL, t=15.428, 8.885, 11.445, all P<0.05]. The VAS scores in the control group and observation group after treatment were (4.57±0.79)points, (2.12±0.41)points, respectively, which were significantly lower than those before treatment[(8.68±1.40)points, (8.72±1.38)points, t=16.170, 28.995, all P<0.05], which of the observation group was significantly lower than that of the control group(t=17.409, P<0.05). After treatment, the serum levels of TNF-α and hs-CRP in the control group and observation group were (2.61±0.20)pg/mL, (6.40±1.36)mg/L and (1.13±0.12)pg/mL, (3.01±1.02)mg/L, respectively, which were significantly lower than those before treatment[(3.95±0.31)pg/mL, (11.35±3.14)mg/L and (4.02±0.35)pg/mL, (11.52±3.20)mg/L, t=22.972, 9.149, 49.400, 16.025, all P<0.05], while the serum levels of IL-2 of the two groups after treatment were (4.13±0.75)μg/mL, (7.12±0.91)μg/mL, which were significantly higher than before treatment[(1.98±0.51)μg/mL, (1.87±0.60)μg/mL, t=14.993, 30.462, all P<0.05]. The serum levels of TNF-α and hs-CRP of the observation group were significantly lower than those of the control group(t=40.132, 12.612, all P<0.05), serum level of IL-2 of the observation group was significantly higher than that of control group(t=16.036, P<0.05). Conclusion Fuyankangfupian can significantly reduce the abdominal pain, bleeding time and blood loss, ease abdominal pain and inflammation of the patients with miscarriage caused by chronic endometritis, it is worthy clinical application. Key words: Fuyankangfupian; Endometritis; Miscarriage; Inflammatory factor; Treatment outcome