Abstract
Background Hyperproliferation of smooth muscle cells (SMCs) plays a key role in allograft arteriosclerosis. This prompted us to investigate the effect of the novel immune modulator and synthetic sphingolipid FTY720 on apoptosis of SMCs. Methods Rabbit SMC cultures were treated with FTY720 and apoptosis and necrosis were detected by fluorescence microscopy. Results We investigated dose- and time-dependent effects of FTY720 and found that clinically relevant low doses of FTY720 (<1 μmol/L) did not induce apoptosis, whereas 10 μmol/L FTY720 induced apoptosis after 48 hours incubation. Conclusion At doses of FTY720 used in clinics for treatment of renal allografts and multiple sclerosis. FTY720 did not induce SMC apoptosis.
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