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Abstract
Aim: To study the efficacy of Fresh Frozen Plasma (FFP) transfusion practice in patients with coagulation abnormalities varies in clinical practice.
 Study Design: A retrospective study.
 Place and Duration of Study: This study was conducted in Department of Transfusion Medicine, SMCH, Chennai, between the period of 2019-2020.
 Methodology: The medical records of each patient receiving FFP transfusions that occurred in patients with coagulation abnormalities were reviewed and the data were collected based on pre-and post transfusion PT (>12 sec), APTT (>70sec) and INR (>1.5) and then analysed statistically. Patients with normal coagulation parameters were excluded from study.
 Results: A total of 1259 units of fresh frozen plasma were transfused to 315 patients between the year 2019-2020. Of the 1259 units transfused 1133 units where transfused to 283 patients with coagulation abnormalities. Apparently 32 patients were excluded from the study as they had normal coagulation profile. Among 251 patients, 37 patients PT were greater than 12 seconds before FFP transfusion out of which the PT was corrected for 14 patients (37.8%) after FFP transfusion. In 228 patients APTT was greater than 70 seconds before FFP transfusion, out of which APTT was corrected in 18 patients (8%) after transfusion. INR values for all 251 patients were greater than1.5 before FFP transfusion, out of which INR was corrected in 84 patients (29%) after transfusion.
 Conclusion: We conclude that FFP transfusions in patients with coagulation abnormalities maycorrects the defect only in less percentage of patient population, as in our study it corrects only an average of 31% of patient population.
Highlights
Fresh frozen plasma transfusion is mainly used in correcting multiple clotting factor deficiency and many international guidelines are present that recommend its use in correcting the deficiencies and in bleeding [1,2]
Among 251 patients, 37 patients PT were greater than 12 seconds before Fresh Frozen Plasma (FFP) transfusion out of which the PT was corrected for 14 patients (37.8%) after FFP transfusion
In 228 patients APTT was greater than 70 seconds before FFP transfusion, out of which APTT was corrected in 18 patients (8%) after transfusion
Summary
Fresh frozen plasma transfusion is mainly used in correcting multiple clotting factor deficiency and many international guidelines are present that recommend its use in correcting the deficiencies and in bleeding [1,2]. The use of fresh frozen plasma has been increasing steadily and mainly used in patients in intensive care units who are critically ill and in patients with excessive active bleeding [1,2,3]. In recent years along with its use in active bleeding and in ICU’s it is being used prophylactically even in patients with mild coagulopathy before surgeries or other invasive procedures [3,4,5,6,7]. 11], reveal there is no correlation between bleeding and mild abnormalities in coagulation profile. Inspite of such results the use of prophylactic FFP transfusion for mild abnormalities has increased [4]. Many retrospective studies suggest that bleeding is low following an invasive procedure and the requirement of transfusion is very low [2]
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