Abstract
Abstract Adenosinetriphosphatase (ATPase) activities of mouse brain synaptosomal fraction and microsomal and purified mitochondrial fractions of mouse brain and liver were studied following acute and chronic ethanol administration. At 1 and 3 hours after intraperitoneal injection of 4g/kg body weight of ethanol, brain mitochondrial activity was significantly increased over levels in untreated animals by 34% and 57% respectively. A significant increase in liver mitochondrial ATPase activity was observed 3 hours after the injection of ethanol. After 2 weeks of continuous oral ethanol administration, ATPase activities in the mitochondrial fractions of brain and liver were significantly increased 64% and 27% over levels in untreated animals. The increase in mitochondrial ATPase activity was shown to be predominantly Mg ++ dependent, ouabain insensitive ATPase and not DNP-activated ATPase. Synaptosomal and microsomal ATPase activities were not affected by acute and chronic in vivo administration of ethanol.
Published Version
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