Abstract
ObjectiveLeft ventricular wall stress has been investigated in a variety of populations, but the effect of food intake has not been evaluated. We assessed whether left ventricular wall stress is affected by food intake in healthy subjects.MethodsTwenty-three healthy subjects aged 25.6 ± 4.5 years were investigated. Meridional end-systolic wall stress (ESS) and circumferential end-systolic wall stress (cESS) were measured before, 30 minutes after, and 110 minutes after a standardised meal.ResultsBoth ESS and cESS decreased significantly (P < 0.001) from fasting values 30 minutes after the meal, and had not returned to baseline after 110 minutes. ESS decreased from 65 ± 16 kdynes/cm2 (fasting) to 44 ± 12 kdynes/cm2 30 minutes after, and to 58 ± 13 kdynes/cm2 110 minutes after eating. cESS decreased from 98 ± 24 kdynes/cm2 to 67 ± 18 kdynes/cm2 30 minutes after, and to 87 ± 19 kdynes/cm2 110 minutes after the meal.ConclusionThis study shows that left ventricular wall stress is affected by food intake in healthy subjects.
Highlights
End-systolic wall stress has been used as a measurement of myocardial afterload, the counter force limiting left ventricular ejection
Circumferential fiber shortening is limited by circumferential end-systolic wall stress, whereas longitudinal fiber shortening is limited by meridional end-systolic wall stress (ESS) [1,2]
The purpose of the present study is to evaluate the hypothesis that food intake, in healthy volunteers, may have an effect on meridional and circumferential wall stress, as this has not previously been investigated
Summary
End-systolic wall stress has been used as a measurement of myocardial afterload, the counter force limiting left ventricular ejection. To put it circumferential fiber shortening is limited by circumferential end-systolic wall stress (cESS), whereas longitudinal fiber shortening is limited by meridional end-systolic wall stress (ESS) [1,2]. Digestion of food is known to significantly alter hemodynamics [7,8,9,10] and may affect wall stress, as loading conditions are altered. The purpose of the present study is to evaluate the hypothesis that food intake, in healthy volunteers, may have an effect on meridional and circumferential wall stress, as this has not previously been investigated
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