Abstract
Cadmium is a toxic heavy metal, which is mainly absorbed by gastro intestinal tract (GIT). This absorption increases when there is a decrease in the level of iron in body stores. This study was carried to find out that the intake of ferrous sulphate affects the absorption of cadmium chloride from gastro intestinal tract (GIT) of mature rabbits exposed chronically to polluted water with cadmium chloride (CdCl2). Four to five months old rabbits were equally divided into three groups: Control (A), this group offered ordinary tab water, the second treated group (B), offered tap water containing 80 parts per billion (ppb) CdCl2. The third treated group (C), offered tap water containing (80 ppb) CdCl2 with 4mg of ferrous sulphate that are given orally once a day. Cadmium concentration in serum was measured using atomic absorption instrument at the end of experiment which extended for 8 weeks. The results revealed that Cd concentration was increased significantly in the 2nd group (B) as the CdCl2 level in serum reached 2.057 ppb, while it decreases significantly in the 3rd group (C) where the level decreased to 0.455 ppb compared to control group (A). These findings concluded that the supplementing food with iron compounds led to a decrease in serum cadmium levels, where ferrous competes with the absorption of Cd.
Highlights
Cadmium is a widespread, very toxic heavy metal, which naturally exists in the earth’s crust
Cadmium is a toxic heavy metal, which is mainly absorbed by gastro intestinal tract (GIT)
This study was carried to find out that the intake of ferrous sulphate affects the absorption of cadmium chloride from gastro intestinal tract (GIT) of mature rabbits exposed chronically to polluted water with cadmium chloride (CdCl2)
Summary
Very toxic heavy metal, which naturally exists in the earth’s crust. It exists as a minor component in most zinc ores. Cadmium is utilized in the industry because of its non-corrosive properties in metal coating [1]. In PVC, cadmium is used as heat, light, and weathering stabilizers. Several researchers suggested that complex of heavy metals including cadmium has a great potential for treatment of wide variety of cancers but their use is often limited due to toxic effects. Iron deficiency is a risk factor for increasing cadmium blood and urine among never-smoking, premenopausal, non-pregnant US women [8]. Cadmium inhibits iron absorption only at low to normal levels of dietary iron [9]. In the present study, ferrous sulphate is chosen as trace element supplement that influences on Cadmium chloride absorption from GIT and its level in serum of mature rabbits exposed chronically (8 weeks) to Cd in drinking water
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