Effect of fenofibrate in comparison to metformin on the biophysical and biochemical parameters in diabetic albino wistar rats

Abstract

Introduction: Diabetic endothelial dysfunction is accompanied by increased oxidative stress and upregulated proinflammatory and inflammatory mediators in the endothelial vasculature. Activation of peroxisome proliferator-activated receptor-alpha (PPAR-α) results in antioxidant and anti-inflammatory effects. Aim of this study is to investigate the effect of fenofibrate, a PPAR-α activator, on the oxidative stress, inflammation and its anti-oxidant effect in streptozotocin diabetic rats and to compare the effectiveness of FF with that of Metformin (Met). Material & Methods: This experimental animal study was conducted at animal house. The sample size included 174 albino wistar rats divided into 3 Groups, one control groups (C )Diabetic and untreated and two test groups .T1 -Diabetic and treated with metformin 75 mg/kgwt/day) and T2 (T – Diabetics treated with fenofibrate 100 mg/kgwt/day), with 58 rats in each group (29 male & 29 female). All the rats were treated with streptozotocin intra peritoneally and the diabetic state was induced. T1 group was treated with metformin 75 mg/kg/wt/day. The T2 group of rats were treated with Feno fibrate (FF) at a dose of 100 mg/kgwt/day.