Effect of fast-track surgery on inflammatory response and immune function in patients with laparoscopic distal gastrectomy

Abstract

Enhanced recovery after surgery can reduce immunosuppression and inflammation in patients with laparoscopic distal gastrectomy The aim of this study was to investigate the effect of fast-track surgery on inflammatory response and immune function in patients with laparoscopic radical gastrectomy. A total of 244 patients undergoing laparoscopic radical gastrectomy for gastric cancer from January 2014 to December 2017 were collected. The patients were divided into fast-track surgery (FTS) and traditional groups. The inflammatory index, immune index, and postoperative complications were measured before and after the operation. There was no significant difference in immune index between the two groups on the day before operation and one day after operation, all P > 0.05. On POD3 and POD6, the expression of CD3+, CD4+, CD4+/CD8+, IgG, IgM, and IgA in the FTS group was higher than that in the traditional group and the difference was statistically significant (P < 0.05).There was no significant difference in inflammation index between the two groups on the day before operation; on POD1, POD3, and POD6, the expression of IL-6, TNF-α, and CRP in the FTS group was lower than in the traditional group and the difference was statistically significant (P < 0.05). The total postoperative complications in the FTS group were significantly lower than those in the traditional group and the difference was statistically significant (P < 0.05). Fast-track surgery can effectively reduce the degree of postoperative inflammatory reaction and the incidence of postoperative complications compared with the traditional group and has a smaller impact on the body’s immune function, which is worthy of promotion in clinical practice.