Effect of ezetimibe combined with statins on elderly CHD patients with hyperlipidemia

Abstract

Objective To investigate the clinical efficacy of ezetimibe combined with statins on elderly coronary heart disease (CHD) patients with hyperlipidemia. Methods A total of 120 elderly CHD patients with hyperlipidemia were randomly divided into joint group and control group, with 60 cases in each group. The patients in control group were treated with rosuvastain alone, and the patients in joint group were treated with ezetimibe based on the treatment in control group. The clinical efficacy, blood lipids and major adverse cardiac events (MACE) of the two groups were compared. Results The total efficiency of the joint group after treatment was 88.3%, which was significantly higher than that of the control group(58.3%), the difference was significant (χ2=13.807, P<0.01). Compared with control group, the levels of TC, TG and LDL-C were lower but the level of HDL-C was higher than the joint group, the differences were significant (t=8.911, 3.722, 10.477, 6.149, P<0.01). The incidence of MACE of the joint group was lower than that of control group after half a year of following-up, the difference was significant (χ2=8.539, P=0.003). Conclusions Ezetimibe combined with statins has good clinical effect on elderly CHD patients with hyperlipidemia, which is worth popularizing in clinics. Key words: Ezetimibe; Rosuvastatin; Coronary heart disease; Hyperlipidemia