Abstract

Long-term exogenous insulin injection can cause hematopoietic disorders that can affect hematological status. This study aimed to examine the effect of exogenous insulin injection on hematological status in rats (Rattus norvegicus L.). This study uses a completely randomized design with 3 groups and not similar replications. The groups were P0 : control, P1 and P2 : rats were injected with exogenous insulin at a dose of 2 IU/Kg body weight for 14 days and 28 days subcutaneously in the abdomen. Hematological status was observed at the end of treatment, namely erythrocytes, hemoglobin concentration, hematocrit value, erythrocyte index, total and differential leukocytes, number of platelets. Data were analyzed using one-way ANOVA and LSD post hoc test. The results show that insulin injection at dose 2 IU/Kg did not have a significant effect on erythrocytes, hemoglobin concentration, hematocrit value, mean corpuscular volume, mean corpuscular hemoglobin concentration, number of leukocytes, number of neutrophils, number of lymphocytes, and number of platelets (p > 0.05), but had a significant effect on mean corpuscular hemoglobin and number of monocytes (p < 0.05). It can be concluded that exogenous insulin injection for 14 days can cause disturbances in hematological status in the form of a decrease in mean corpuscular hemoglobin and an increase in the number of monocytes.

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