Abstract

Moderate-intensity exercise is considered to enhance immune function and to be useful for preventing acute upper respiratory infections and similar conditions. Many people practice low-intensity short-duration exercise with the expectation of a beneficial effect on immunocompetency. However, it is difficult to affirm the existence of definite evidence of such a benefit. In this article, we discuss the effects of low-intensity short-duration exercise on cell-mediated immunity, and contrast them to the effects of high-intensity and long-duration exercise. Whereas high-intensity exercise induces inflammation and reduces cell-mediated immune system function, low-intensity exercise does not appear to have a large effect on either inflammation or cell-mediated immune function. Low-intensity exercises such as walking and yoga, which are helpful to relieve stress, cannot be considered as harmful to the immune system. Although yoga was shown to impose fewer restrictions on breathing and physical strain, the evidence that yoga enhances cell-mediated immunity remains insufficient. Therefore, further studies are needed to examine the exercise mode that may be most effective for improvement of immune functions.

Highlights

  • It is well known that exercise promotes cell-mediated immune system function by releasing anti-inflammatory cytokines (IL-4, IL-1ra, IL-5) at the site of injuries [1]

  • Helper T (Th) cells, which play a central role in cell-mediated immunity, are induced cytotoxic T (Tc) cells, macrophages and natural killer (NK) cells via immunomodulatory cytokines such to differentiate into type 1 helper T (Th1) cells by interleukin (IL)-12, which activates as IL-2 and interferon-gamma (IFN-γ) [11]

  • Endurance exercise causes an increase and activation of blood neutrophils; this might be considered as an excessive biological reaction that leads to muscle and organ damage and systemic inflammation rather than to the activation of immunocompetence [23]

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Summary

Introduction

It is well known that exercise promotes cell-mediated immune system function by releasing anti-inflammatory cytokines (IL-4, IL-1ra, IL-5) at the site of injuries [1]. Exercise intensity and duration have been demonstrated to have a great impact on immune system function [2,3,4,5,6]. This beneficial effect of exercise is due to the anti-inflammatory effects of exercise mediated by the downregulation of Toll-like receptors and/or cytokines [6]. Low-intensity short-duration exercise may have a beneficial effect on cell-mediated immune system function [3,8]. We discuss the effects of cytokine dynamics that result from low-intensity short-duration exercises on cell-mediated immunity, in contrast to the effects of high-intensity and longduration exercise

Function and Control Mechanism of Cell-Mediated Immunity
Effects of High-Intensity andand
Effects of Moderate-Intensity Exercise and Training on Immune Variables
Findings
Conclusions and Challenges for the Future

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