Abstract
Diclofenac sodium were taken as a model drug and belongs to NSAIDS. Diclofenac sodium prevents production of prostaglandins and thus exerts its analgesic action and inhibits leukocyte formation to induce anti-inflammatory action. It is tremendously recommended to reduce and overcome signs and symptoms of rheumatoid arthritis, osteo-arthritis andankylosing spondylitis. This present study was to investigate the dissolution profile and release kinetics of modified release diclofenac sodium microspheres containing sodium alginate and Eudragit S-100. Microspheres were prepared by using ionotropic gelation technique and coated by using coacervation phase separation method using different ratios of eudragit S100 which is a pH sensitive polymer. Both coated and uncoated diclofenac sodium microspheres were evaluated for % yield, entrapment efficiency, flow property, in vitro percent drug release. which were spherical in shape, were rough and smooth, respectively. The size of the core microspheres ranged from 450 to 550 μm and the size of the coated microspheres ranged from 500 to 700 μm. The core microspheres sustained the release for 12hrs in a pH progression medium mimicking the condition of GIT. The release studies of coated microspheres were performed in a similar dissolution medium as mentioned above. In acidic medium, the release rate was much slower. However, the drug was released quickly at pH 7.4 and their release was sustained up to 24 hrs. Finally, it was concluded that eudragit L100 and ethyl cellulose were appropriate polymers to prepare microspheres of diclofenac sodium as modified release drug delivery system.
Published Version
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