Abstract
1. 1. The effect of ethionine on the incorporation of 32P i into liver phosphatidyl choline and phosphatidyl ethanolamine in female rats was studied in vivo and in vitro. 2. 2. A marked decrease of 32P uptake into phosphatidyl ethanolamine and a striking increase of that into phosphatidyl choline were produced by the intraperitoneal administration of ethionine. Methionine counteracted the effect of ethionine, but ATP did not. 3. 3. Liver slices from ethionine-treated rats, incubated in Krebs-Ringer bicarbonate or phosphate buffer solution, incorporated more 32P into phosphatidyl choline and less into phosphatidyl ethanolamine than slices from saline-treated rats. The slices from ethionine-methionine-treated rats exhibited no decrease in 32P uptake into phosphatidyl ethanolamine. 4. 4. The concentrations of phosphatidyl choline, phosphatidyl ethanolamine, CDP-choline, CDP-ethanolamine, phosphorylcholine and phosphorylethanolamine in livers of female rats were determined.
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