Abstract
Effects of ethanol on permeability and ion transport in the isolated dog gastric mucosa were studied. The unidirectional fluxes of urea and sodium were increased slightly in 3% (v/v) ethanol and markedly in 20% (v/v) ethanol, but those of chloride only increased in 20% ethanol. The increase in the unidirectional fluxes of electrolytes in 20% ethanol was associated with increased ionic conductance (decreased resistance). Measured as net ionic flux at zero electrochemical potential difference, the active transport of chloride, sodium and hydrogen ions was inhibited by 20% ethanol. Sodium ion and hydrogen ion transport were also inhibited after 5 minutes in 3% ethanol. We conclude that ethanol increases permeability and inhibits ion transport in the isolated dog gastric mucosa.
Published Version
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