Abstract
Objective To study the effect of estrogen on acute lung injury patients with paraquat (PQ) poisoning. Methods Ninety-six SD rats were randomly (random number) divided into four groups, namely control group, estrogen control group, poisoning of Paraquat (PQ) and PQ treated with estrogen group. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase in rat lungs tissue were determined at different intervals. The histopathological changes of lung tissue of rats were observed under optic microscope in each group at 14 day. Results The estrogen decreased the concentration of MDA and activity of SOD and glutathione peroxidase in case of acute poisoning of Paraquat (P <0.05). At same time, treatment with estrogen could alleviate the lung injury and inflammatory cell infiltration in the interstitium of lung. Conclusions The estrogen can reduce the degree of oxidative stress in case of acute poisoning of Paraquat, alleviating the lung injury. Key words: Acute poisoning of paraquat; Estrogen; Acute lung injury; Oxidative stress; Rat; Malondialdehyde; Superoxide dismutase; Glutathione peroxidase; Poisoning
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
