Abstract
Summary Estrogen was found to enhance significantly the production of immune hemolysin for sheep red cells in C57BL mice, whereas in C3H mice a moderate inhibition of hemolysin titers was noted in estrogen-treated animals. Cortisone was much more effective in depressing antibody titers for sheep red cells in mice of strain C3H than in those of strain C57BL. Normal, untreated C57BL females showed significantly higher hemolysin titers than did C57BL males. On the other hand, no such difference was found in males and females of strain C3H. The implications of these findings were discussed in relation to the innate difference in immune response characterizing C57BL and C3H strains and in connection with the hormonal physiology of these strains. Some generalizations were made regarding the effect of hormones on immune responses.
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