Abstract
1. 1. Glucose utilization was measured in human, pig, cow, rabbit, mouse and rat red blood cells. Mean values are variable from species to species and range from 0.27 μmol/hr/ml RBC for pig erythrocytes to 2.85 μmol/hr/ml RBC in mouse red cells. 2. 2. The amount of glucose metabolized through the pentose phosphate pathway ranges from 2.1 to 7.0% of the total glucose utilized. 3. 3. Variable recycling values have been obtained for the red blood cells of the species studied but with the exception of mouse (14 nmol/hr/ml RBC) all the other values do not show great differences. 4. 4. The hexokinase levels of the erythrocytes studied when correlated with the glucose utilization and the pentose phosphate pathway show that this enzyme could play a central role in the regulation of glucose metabolism.
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