Abstract
The liver lipids of rats fed on the diets deficient in essential amino acid (EAA)* were compared with those of the corresponding pair-fed controls. The concentration and composition of hepatic lipids are modified specifically according to each EAA deficiency. In general, feeding the diets deficient in EAA resulted in the decrease in the concentration of hepatic phospholipid. This was most remarkable in Lys, Val or Leu (and perhaps Phe or Trp) deficiency. The decrease in the concentration of hepatic phosphatidylethanolamine (PE) was more predominant than that of phosphatidylcholine (PC). The concentration of triglyceride increased in rats fed on the diets devoid of each EAA except Val. The response of cholesterol concentration was scattering. In the liver and its microsomal PC percentage of linoleate increased in Ileu, Thr, Met or Leu (and Phe) deficiency and that of arachidonate decreased in Met, Leu or Val (Phe) deficiency, respectively. Consequently, the ratio of arachidonate to linoleate reduced in Thr, Ileu or Met deficiency. These observations, together with those demonstrated previously, indicate that the quantity and the quality of dietary protein significantly influence on the metabolism of fatty acids, particularly linoleate and arachidonate.
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