Abstract
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Highlights
In the experiment, the effect of intravenous administration of epinephrine on the ultrastructure of the epithelium of rabbits’ terminal bronchioles was studied
We described statistically significant changes in the secretory activity of Clara cells accompanied with the development of signs of pathological alteration of their cytoplasm after the administration of acetylcholine (Uhlík et al 1999)
The signs of the pathological alteration of the Clara cells were identical to those observed after the parenteral administration of polycyclic aromatic compounds (Plopper et al 1992ab;1994a; Van Winkle et al 1995; Lakritz et al 1996), inhalation of trichloroethylene (Giovanetti et al 1998) or after inhalation of ozone (Harkema et al 1993; Plopper et al 1994b)
Summary
The effect of intravenous administration of epinephrine on the ultrastructure of the epithelium of rabbits’ terminal bronchioles was studied. Laboratory rabbits were injected with 10 μg of epinephrine per kg of body weight and the material for the electron microscopic examination was collected 5 and 20 minutes post exposure In both experimental groups, the cells of the epithelium of terminal bronchioles revealed signs of pathological alteration. Many authors have studied the mechanisms controlling the function of secretory cells in airways Their interest has been concentrated mostly on the mucus-producing goblet cells and on the secretory cells situated in the submucosal glands that produce the major part of airway secretion. The stimulating effect of cholinergic stimulation on the secretory function of the tracheal goblet cells was demonstrated in rabbits (Konrádová et al 1996a,b). The effect of the adrenergic stimulation on the secretion of goblet cells and submucosal glands was studied.
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