Abstract
Background: Pulpitis is an inflammatory pulp that can occur due to mechanical trauma that causes perforation of the pulp. Treatment of pulpitis Emergency frequently using Eugenol. High concentrations of Eugenol have a cytotoxic effect that causes local necrosis and inhibits the recovery process. An alternative consideration with Epigallocatechin 3-gallate (EGCG) which has good antioxidant properties and increases the complexity of inflammation by inhibiting the production of inducible nitric oxide synthase (iNOS) and nitric oxide so that levels migration of inflammatory cells to the area of injury will decrease and inflammation will occur shorter then initiates the proliferation so the recovery process and tissue repair will be more rapidly occurring. One of the cells that support tissue repair is macrophages. Purpose: this study aims to explain the effect of EGCG on the number of macrophage cells in pulp inflammation with mechanical injury. Methods: The study used 24 Wistar rats teeth divided into four groups, namely control (C), and 3 treatment groups T1, T2, and T3. Each group consisted of 6 rats prepared, then T1 was named EGCG hydrogel 60 ppm, T2 was given EGCG hydrogel 90 ppm, while T3 was given EGCG hydrogel 120 ppm. On the 3rd day, Wistar rats were decapitated to continue making HPA preparations. Results:This study showed a significant difference in each group (p< 0.05) using One-Way Anova analysis. Conclusion: EGCG hydrogel 90 ppm is effectivein increasing the number of macrophage cells.
Highlights
Pulpitis or inflammation of the pulp is experienced by many Indonesian people
Data that were normally distributed were forwarded with Tukey HSD to determine differences between treatment groups, meaningful differences were marked by sig values smaller than 0.005 (p
Macrophages with HE staining microscopically appear as round mononuclear cells with oval or kidney-shaped nuclei that are eccentric with a cytoplasm containing medium density.4Data obtained from histopathological readings (HPA) shows the dominance of macrophage cells
Summary
Pulpitis or inflammation of the pulp is experienced by many Indonesian people. Based on the results of basic health research in 2010 the prevalence of pulpitis in Indonesia is quite high. The number of pulpitis patients is approximately 160,000 within one year.1Based on the research of AlHisayat et al, (2006) showed that of 204 pulpitis teeth that had perforation, 90 teeth (44.1%) were due to mechanical trauma.[2]. Acute pulpitis occurs when inflammation first occurs in the pulp and has a characteristic sharp pain, whereas chronic pulpitis is pulpitis that has occurred repeatedly and has dull pain.[3] Pulpitis is similar to inflammation of connective tissue in other parts of the body that causes pain where there are cells associated with inflammatory reactions namely polymorphonuclear leukocytes and mononuclear leukocytes including macrophages and lymphocytes.[4]. Purpose: this study aims to explain the effect of EGCG on the number of macrophage cells in pulp inflammation with mechanical injury. Conclusion: EGCG hydrogel 90 ppm is effectivein increasing the number of macrophage cells
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