Abstract
Introduction: Effects of juvenile diabetes on the central nervous system are less well documented. Effective management of T1DM is another major challenge as insulin is the only available effective treatment. Hence, easily available, affordable, non-invasive therapies like enriched environment are the need of time. Objectives: The present study aimed to determine the effect of an enriched environment on cognitive and behavioral changes in juvenile diabetic rats. Methods: Diabetes was induced in 25 days old, albino Wistar rats, by streptozotocin (STZ). Animals were reared in an enriched environment and treated with herbal formulae with Salacia R and Clitoria T. Then, rats were tested in the elevated passive maze, passive avoidance box and Morris water maze (n=6). Values are expressed as means ± SE and differences assessed by using one way ANOVA test followed by Bonferroni multiple comparison test. Results: Statistically significant (p<0.05) difference was observed between the enriched environment and diabetic group of rats. Additionally, effects are comparable to conventional insulin therapy, in the animals which received combined therapy (SR+CT+EE) (p<0.01). Conclusion: Authors have shown that diabetic rats reared in enriched housing conditions, showed improved cognitive measures compared to diabetics. The combined treatment is found to be more beneficial in restoring normoglycemic levels and preventing behavioral and cognitive deficits.
Highlights
Effects of juvenile diabetes on the central nervous system are less well documented
Authors have shown that diabetic rats reared in enriched housing conditions, showed improved cognitive measures compared to diabetics
The intragroup analysis showed a significant increase in Fasting Blood Sugar (FBS) values on postnatal day 30 (p
Summary
Effects of juvenile diabetes on the central nervous system are less well documented. Effective management of T1DM is another major challenge as insulin is the only available effective treatment. Latest figures from the International Diabetes Federation-Diabetes Atlasshowed that presently 387 million people are living with diabetes. It is expected to rise up to 592.8 million by the year 2035 [1]. Diabetes mellitus is a clinical syndrome, characterized by hyperglycemia due to an absolute or relative deficiency of insulin or non-responsiveness of tissues to insulin. Long-standing concern about the deleterious effects of diabetes on CNS has enhanced with the increasing incidence of type 1 diabetes mellitus (T1DM) in children [3]. Many researchers have shown the relationship between neuropsychological changes and T1DM of early onset [4,5,6]. Diabetes-induced behavioral and cognitive changes to appear to be associated with several factors
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