Abstract
Objective: To observe the effect of electro-acupuncture pretreatment at Neiguan Point (PC6) on the Nitric Oxide (NO), Nitric Oxide Synthase (NOS) of rabbit serum (which are endogenous protective substances) during experimental myocardial ischemia-reperfusion injury. Methods: To divide 40 New Zealand white rabbits (half male and half female) randomly into sham group, ischemia-reperfusion model group, Electro-acupuncture Pretreatment at Neiguan Point group, Electro-acupuncture pretreatment at Lieque Point group, Electro-acupuncture Pretreatment at Hegu Point group. Create a model of myocardial ischemia-reperfusion by coronary artery ligation, 30 min of ligation and 60 min of reperfusion; each of the Electro-acupuncture Pretreatment groups have been pretreated by electro-acupuncture for 5 days (20 min/day) before coronary artery ligation. Using Enzyme-Linked Immunosorbent Assay (ELISA) to detect the levels of NO, NOS in the serums of each group. Results: compared with the sham group, the levels of NO, NOS in the serums of the ischemia-reperfusion group decrease (P < 0.05); compared with the ischemia-reperfusion group, the levels of NO, NOS in the serums of the Electro-acupuncture Pretreated at Neiguan Point group increase significantly (P < 0.01). Conclusion: Electro-acupuncture Pretreatment at Neiguan Point, Pericadium Meridian can effectively raise the levels of myocardial NO, NOS [1].
Published Version
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