Abstract
The influence of early protein-calorie malnutrition on synaptic transmission in the rat prefrontal cortex was studied by evoking direct cortical responses with different trains of threshold electrical pulses. Malnutrition resulted in a requirement for increased pulse train stimulating current, reflecting a diminished release of neurotransmitter from the preterminal endings. In addition there was an increase in the time constant of pyramidal cells, indicating that axodendritic synapses have a disability for integrating high frequency inputs at the post synaptic level. It is concluded that early malnutrition alters dynamic properties of axodentritic synapses at both the pre- and the postsynaptic levels.
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