Effect of duration in early high volume hemofiltration on severe acute pancreatitis with acute lung injury

Abstract

Objective To investigate the effect of duration in high volume hemofiltration (HVHF)on lung function of patients with severe acute pancreatitis(SAP)in early stage.Methods Forty-nine patients who suffered from SAP with acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)from Augest 2006 to April 2009 were randomly divided into group Ⅰ(HVHF for 8 hours)and group Ⅱ(HVHF for 72 hours).APACHE Ⅱ score,oxygenation index,the improvement rate(including cure rate)of ALI/ARDS,the ease and time of mechanical ventilation,complications in acute stage,complications related with HVHF,outcome,and medical cost of two groups were compared.Results ①The oxygenation index and APACHEⅡ of two groups on the 3rd.14th day after admission improved(P＜0.05).But there was no significant difference between two groups on the 3rd,14th day.②The improvement rate(including cure rate)of ALI/ARDS of two groups on the 3rd,14th day after admission was higher than that on the admission(P＜0.05).But there was no significant difference between two groups on the 3rd,14th day.③There was no significant difference in the case and time of mechanical ventilation,complications in acute stage(multiple organ dysfunction syndrome,acute renal failure,abdominal compartment syndrome,vessel infection,hypotension between two groups.But there was statistical significance in medical cost between two groups(P＜0.05). Conclusion Early continuous 8 hours HVHF can improve the function of lung in 72 hours of SAP onset,and save medical cost. Key words: Severe acute pancreatitis; Acute lung injury; High volume hemofiltration; Duration