Abstract
The pharmacokinetics of hydrocortisone were examined following single doses of 5-, 10-, 20-, and 40-mg hydrocortisone suspensions to healthy male volunteers. Endogenous hydrocortisone was suppressed by giving 2mg of dexamethasone the night before hydrocortisone administration. Plasma samples obtained serially for 12hr after hydrocortisone administration were assayed by reversed-phase high-pressure liquid chromatography using a fixed-wavelength (254nm) UV absorbance detector. Drug absorption was rapid, with mean maximum plasma hydrocortisone concentrations occurring within 60min of dosing. Subsequent drug elimination was monophasic with mean elimination half-lives increasing from 1.2hr for the 5-mg dose to 1.7hr for the 40-mg dose. Increases in AUC and Cmax with increasing dose were linear but not directly proportional to dose size. This was attributed to dose-dependent absorption or to loss of drug during the first-pass through the liver.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
